IGF2 and cancer: Additionally, TTS mapping exhibits trimethylation of hystone 3 lysine in the position 27 (H3K27met3) and an absent of trimethylation of hystone 3 lysine in position 4 (H3K4met3) of IGF2 gene region observed in several cancer cell types, which suggests that transcription of the both IGF2 gene and mir-483 is suppressed.