In the FLT3-wt AMLs, the constitutive STAT5 activation varied between HSC and MPP fractions, whereby AML 2007-272 contained high constitutive STAT5 activation within the HSCs, while the STAT5 activation in AML 2005-016 was more pronounced within the CMP/GMP fractions. Here, FLT3 is linked to acute myeloid leukemia.