APC and colorectal carcinoma: NKD1 mutations were not detected in 32/40 MSI-CRC tumors that harbor mutations in other Wnt-pathway genes including APC, CTNNB1, AXIN2, and TCF7L2, but were found in 2 of the remaining 8/40 tumors without lesions in these known Wnt-pathway genes (p = 0.036, one-tailed Fisher's exact test) (Table 1; see Materials and Methods).