HACE1 and neoplasm: In common with other cancers, WTs also show tumour suppressor gene silencing which includes genes such as HACE1 (73% of tumours analysed) [6], RASSF1 (56%) [7], CASP8 (43%), MGMT (30%), RASSF5/NORE1 (15%), and CDKN2A (10–15%) [8].