Analysis of PCDH methylation in microdissected perilobar nephrogenic rests, presumptive WT precursor lesions, revealed no PCDH hypermethylation (Figure S3) but hypermethylation was evident at the PCDHGA3 and PCDHGB4 genes in a set of stromal-predominant tumours (Figure S4). The gene discussed is PCDHGB4; the disease is neoplasm.