To evaluate if the inhibitory action of GD3 on the cSrc/NF-κB pathway induced by hypoxia was cell type specific or common to other hepatoma cells, HepG2 cells were cultured under hypoxic conditions examining c-Src tyrosine phosphorylation and Mn-SOD expression after GD3 administration. Here, NFKB1 is linked to hepatocellular carcinoma.