Loss-of-function germline mutations in FOXL2 are associated with blepharophimosis–ptosis–epicanthus–inversus syndrome [BPES;OMIM#110100]; an autosomal dominant developmental disorder characterized by eyelid malformations and premature ovarian failure due to a dysfunction of granulosa-cells [10]. The gene discussed is FOXL2; the disease is Eyelid malformation.