Obesity with fat deposition in abdominal adipose tissues is implicated in the accumulation of hepatic TG through an increased influx of FFA into hepatocytes from hypertrophied adipocytes [7], [8], and/or through alterations of the secretion of adipokines including adiponectin and resistin that regulate, respectively, fat burning and fat storage in the liver [8], [10], [11], [15]. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.