In agreement with this, we show here that the serum level of alanine aminotransferase (ALT) was significantly higher in wild-type mice fed HF diets for 8 weeks than in wild-type mice fed normal diets, and the serum levels of both ALT and aspartate aminotransferase (AST) were markedly increased after 16 weeks of HF feeding (Table 1). This evidence concerns the gene GPT and hydrops fetalis.