GPI and sarcopenia: Other studies on gene expression that used caloric restriction (CR) or exercise training for preventing sarcopenia have reported that CR either stimulated glycolysis, by the up-regulation of enzymes such glucose-6-phosphate isomerase, and FA synthesis, by over-expressing Fasn[28]–[30], or, in agreement with our findings, induced a transcriptional switch toward an increase of FA metabolism and a reduction of lipid biosynthesis in the muscle [31].