Other examples which could be studied in a similar way include heparin-induced thrombocytopaenia (frequency 0.5–2%), oesteonecrosis of the jaw from bisphosphonate treatment (prevalence 4–7% in those receiving intravenous bisphosphonates for hypercalcaemia of malignancy), and angio-oedema from angiotensin converting enzyme inhibitors. This evidence concerns the gene ACE and Hypercalcemia.