PPARGC1A and Huntington disease: More recently, impaired activity of PPARγ coactivator 1α (PGC-1α) and its target genes, important for inducing mitochondrial biogenesis and in influencing whether muscle contains slow twitch oxidative or fast twitch glycolytic fibres, has been demonstrated in the muscle and myoblasts of HD patients and the muscle of N171-82Q mice [35].