HTT and Huntington disease: Pancreatic inclusion pathology has been reported in all of the N-terminal Htt transgenic HD models: R6/2 mice [15], [25], [45], [46], R6/1 mice (which express the same exon 1 transgene but at a lower level) [47] and N171-82Q mice [16] and the presence of aggregates has been shown to correlate with islet size [16].