Complete loss of SR-BI in normal chow-fed apoE KO mice causes severe hypercholesterolemia associated with coronary arterial occlusion, myocardial infarction and premature death [11], whereas PDZK1/apoE dKO mice fed either chow or Western high fat diets do not exhibit cardiac fibrosis, myocardial infarction nor premature cardiac death [21]. The gene discussed is PDZK1; the disease is arterial occlusion.