To determine if the relatively high abundance of severely occluded arteries in PDZK1/apoE dKO mice were associated with higher incidence of myocardial infarction, we stained cardiac sections of both PDZK1/apoE dKO and apoE single KO mice with Masson trichrome to identify areas of myocardial infarction and fibrosis (blue stain, Fig. 4, D–E). This evidence concerns the gene APOE and myocardial infarction.