However, the relatively low absolute values and small relative differences for the plasma UC:TC ratios in Paigen diet-fed apoE KO (0.27) and PDZK1/apoE dKO (0.31) mice caste doubt on the importance of this characteristic of plasma lipoproteins in influencing coronary arterial atherogenesis and myocardial infarction in this system. The gene discussed is PDZK1; the disease is myocardial infarction.