In a recent follow-up study, Aβ1–42 was co-delivered with interleukin-4 (IL-4), a cytokine competent in promoting a Th2-biased immune response, via a helper virus-free HSV-1 amplicon (designated HSVIEAβCMVIL-4) into the triple-transgenic mouse model of AD (3xTg-AD), a model that closely recapitulates the pathological hallmarks observed in human AD [116]. This evidence concerns the gene IL4 and Alzheimer disease.