Hence, we sequenced the promoter region of normal and affected individuals homozygous for HLA-DRB1*0301 and discovered that VDRE sequence observed in DRB1*0301 promoters from North Indians is homologous to the VDRE sequence which had been shown to up-regulate the expression of HLA DRB1*1501 allele in Multiple Sclerosis [26]. Here, HLA-DRB1 is linked to multiple sclerosis.