Hence, in the present scenario, while predisposing MHC alleles may be involved in auto-antigen presentation, the VDR haplotypes with ‘F’ and ‘T’ alleles may have a role in increased amount of VDR protein resulting in increased IL-12 production which in turn may lead to other downstream pro-inflammatory immune responses against auto-antigens in T1D. This evidence concerns the gene HLA-C and type 1 diabetes mellitus.