Three (bone morphogenetic protein 4 [BMP4], cofilin 1 [CFL1], and JAW1-related protein [MRVI1]) were found to be markedly upregulated genes in keratoconus, while the remaining five (actin, alpha 2 [ACTA2], gene rich cluster, and C 10 gene [GRCC10], tissue inhibitor of metalloproteinase 3 [TIMP3], tissue inhibitor of metalloproteinase 1 [TIMP1], and somatostatin receptor 1 [SSTR1]) were downregulated. The gene discussed is IRAG1; the disease is keratoconus.