Importantly, in the context of developing new treatment for mRCC, IGF1R signalling has been shown to regulate HIF1-α (manuscript in press), which is a master regulator of hypoxia inducible genes including VEGFR, PDGFR, and TGF-α all of which play important roles in the development of CC-RCC. The gene discussed is KDR; the disease is renal cell carcinoma.