However, the background factors of age, sex, number of lymph node metastasis, tumor size, metastasis, venous involvement and lymphatic involvement were not statistically different between the tumors consisting of the mutated TP53-R72 and the tumors with the mutated TP53-P72 (data not shown). This evidence concerns the gene TP53 and metastatic malignant neoplasm in the lymph nodes.