NOTCH1 and cervical carcinoma: Cervical carcinoma, the second most prevalent cancer in women, is initiated and sustained in part by the presence of high-risk human papillomavirus oncogene expression (zur Hausen, 2002), and has an aberrant expression of Notch1, its ligand Jagged1 and downstream target Hes1 (Ramdass et al, 2007).