Using beads to capture the cytokines, we showed that IL-2, IL-4, IL-5, IL-10, TNF-α and IFN-γ were all secreted, but IFN-γ was found in the highest amount, suggesting that the T cells do become activated and secrete cytokines when activated by MEDI-565 bound to CEA on tumour cells; both Tc1 (Th1) and Tc2 (Th2) type cytokines were detected (Supplementary Figure 4). This evidence concerns the gene IL4 and neoplasm.