Six genes, plant homeodomain finger protein 11 (PHF11), dipeptidyl-peptidase 10 (DPP10), histocompatibility antigen, class I, G (HLA-G), ADAM metallopeptidase domain 33 (ADAM33), neuropeptide S receptor 1 (NPSR1, previously GPR154 or GPRA), and cytoplasmic FMR1 interacting protein 2 (CYFIP2), have been identified to be associated with asthma and asthma-related phenotypes following linkage studies [1-6]. The gene discussed is CYFIP2; the disease is asthma.