We also tested SNPs for their effects on apolipoprotein B (apo B), which measures LDL particle number and may be a better estimator of cardiovascular disease risk than LDL level[20,21], LDL buoyancy which predicts the smaller, denser LDL pattern B phenotype [22] associated with increased risk of coronary artery disease[23], and lipoprotein(a) (Lp(a)) which appears to independently predict risk of coronary artery disease [24] and stroke [25]. The gene discussed is APOB; the disease is Stroke.