RAI1 and Anxiety: The generation of Dp(11)17/Rai1- compound heterozygous animals, determined that restoring the 2n gene dosage of Rai1 alone is sufficient to rescue part of the phenotypes observed in the PTLS mouse model (weight, anxiety and learning difficulties), despite the trisomic copy number of the remaining 18 genes in the SMS critical interval (Table 2) (Fig. (4)).