STAT3 and neoplasm: Signal Transducer and Activator of Transcription 3 (STAT3) is a latent transcription factor in several neoplastic diseases; it normally resides in the cytoplasm and can be activated thought phosphorylation by several cytokines, hormones and growth factor that play their roles using STAT3 activated pathway, regulating different biological responses, like cell development, differentiation, proliferation, motility, and survival [21].