Our results, showing that iAR a) could not be detected in membrane preparations of colon cancer cells (Fig. 5C) and b) that testosterone-HSA effects were manifested even in the presence of the anti-androgen flutamide (Fig 5A, B), imply that the molecular identity of mAR is probably not identical with iAR, targeted to the plasma membrane. Here, PTPRN2 is linked to colonic neoplasm.