These include genes in the pathways for amyotrophic lateral sclerosis (NEF3, NEFL, NEFH), Huntington's disease (CALM3, CLTC, CLTB), neurodegenerative disorders (APLP1, NEFH, FBXW7), Parkinson's disease (GPR37) and prion disease (APLP1, NFE2L2). Here, CALM3 is linked to prion disease.