These include genes in the pathways for amyotrophic lateral sclerosis (NEF3, NEFL, NEFH), Huntington's disease (CALM3, CLTC, CLTB), neurodegenerative disorders (APLP1, NEFH, FBXW7), Parkinson's disease (GPR37) and prion disease (APLP1, NFE2L2). The gene discussed is NFE2L2; the disease is Huntington disease.