These include genes in the pathways for amyotrophic lateral sclerosis (NEF3, NEFL, NEFH), Huntington's disease (CALM3, CLTC, CLTB), neurodegenerative disorders (APLP1, NEFH, FBXW7), Parkinson's disease (GPR37) and prion disease (APLP1, NFE2L2). This evidence concerns the gene CLTC and amyotrophic lateral sclerosis.