Meanwhile, we presented the real-time reverse-transcriptase polymerise-chain-reaction (RT-PCR) study in the same cohort of patients on a battery of core genes which play important roles in inflammation (COX-2, MMP7, MMP9) [14-16] and angiogenesis (VEGF, PDGFRA) [17,18], as well as MYC which was confirmed as a key hypoxia regulator [19], to find the correlation of HIF-1α with these factors that can also affect and reflect tumor behaviors. This evidence concerns the gene PTGS2 and neoplasm.