On univariate analysis, tumor HIF-1α protein expression level was significant for both OS (P = 0.027) and DFS (P = 0.012) (Table 4; Figure 1C and 1D), which were further authenticated on multivariate analysis (P = 0.021 for OS; P = 0.007 for DFS) (Table 5). The gene discussed is HIF1A; the disease is neoplasm.