NSCLC-associated mutant EGFRs have been shown to attain sensitivity to Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17-AAG) which targets the related receptor ErbB2 to degradation by enhancing its lysosomal targeting [37,40,41]. This evidence concerns the gene ERBB2 and non-small cell lung carcinoma.