Conversely, proteins hypophosphorylated (Tumor/Normal phosphorylation spectral count ratio >1) in tumors include the transcription factors STAT1 and STAT5, the protein tyrosine phosphatase PTPN11, the G-protein coupled receptor GPRC5A, and the kinases MAPK1, MAPK3, and TNK2. The gene discussed is MAPK1; the disease is neoplasm.