Huang used a very similar model of hypercholesterolemia in rabbits and demonstrated systolic and diastolic dysfunction with individual myocytes in a perfusion chamber and associated this finding with reduced levels of sarcoplasmic/endoplasmic reticulum Ca2_-ATPase (SERCA)-2 mRNA; we confirmed their bench-top findings with TDI. Here, ATP2A2 is linked to familial hypercholesterolemia.