Among PKC isoforms analyzed in this study by microarray (alpha, beta isoform 1, variant 1, eta, iota, zeta) and quantitative RT-PCR (alpha, beta isoform 1, variant 1 and 2, delta, epsilon, theta) (data not shown), expression of PKC-alpha was significantly lower (FC = 0.17; P < 0.00016), while expression of PKC-theta was significantly higher (FC = 2.34; P < 0.00016) in tumours with KIT mutations compared to those with PDGFRA mutations and wild-type tumours. This evidence concerns the gene KIT and neoplasm.