As we show here, this molecular rearrangement in leukocytes of both VD and glaucoma patients includes an upregulated adhesive protein expression via ICAM1; an induced chemotaxis via P2Y purinoceptors; a mobilization of intracellular Ca2+ response via Na+/Ca2+ exchanger; and a core of tissue-remodeling metalloproteinases. This evidence concerns the gene ICAM1 and glaucoma.