Although, some non-RCTS [12] have claimed that even prevention of mild troponin leaks is associated with better outcome; this was never confirmed and actually contradicted by large scale RCTs: these small CPK leaks (or myocardial infarctions) have never translated into meaningful excess in 30 day or 6 months mortality. The gene discussed is PIK3C2A; the disease is myocardial infarction.