Some proteins from this list have also been identified in tumor studies as clinical outcome predictors (NOV, CLU TNC, POSTN, IGFBP2, LCN2) or mediators of resistance to chemotherapy (CLU, FBLN1, THBS, STIP1, PTGES3, IGFBP4, ATOX1) [32]–[45]. This evidence concerns the gene IGFBP4 and neoplasm.