Interestingly, although the K-ras/Pten model has features of endometrioid ovarian cancer, the data suggested that upregulated secreted proteins identified in mouse plasma with tumor development were more broadly representative of other ovarian cancer histological subtypes, since the human cell lines and ascites derived tumor cells resulted from papillary adenocarcinoma, clear cell and serous subtypes respectively [24], [25]. This evidence concerns the gene PTEN and neoplasm.