Similarly, enrichment in TIMP1, LCN2, IGFBP2, PFN1, SPARC, EEF1B2, CLU, and FBLN2 was observed in conditioned media (CM) collected from ovarian cancer cell lines derived from serous adenocarcinomas (OVCAR-3, SKOV3, CaOV3, OVCAR-5, OVCAR-8), endometrioid carcinoma (TOV112D), clear cell carcinoma (ES-2, IGROV1) compared to conditioned media derived from human ovarian surface epithelium (HOSE, Figure 3C). The gene discussed is IGFBP2; the disease is ovarian carcinoma.