TNFRSF18 and arthritic joint disease: As a mirror image of these findings, GITR-deficient mice (GITR−/−) show significantly reduced inflammatory reactions as compared to wild-type animals in response to various stimuli i.e. chronic lung injury induced by bleomycin instillation, type II collagen-induced arthritis, TNBS (2,4,6-trinitrobenzene sulphonic acid)-induced colitis [25]–[27].