The use in tandem of both lineage-restricted and lineage-nonrestricted transcription factors as components of a diagnostic panel has been used in the evaluation of germ cells tumors where lineage-restricted transcription factors like OCT4 and NANOG can be used alongside lineage-nonrestricted transcription factors like SOX2 [29] and SOX17[66]. This evidence concerns the gene SOX2 and testicular germ cell tumor.