21 of the 22 cases (>95%) demonstrated strong intranuclear CRX immunoreactivity in most tumor cells (Fig 4B, 4D) with strong staining evident in both well-differentiated regions demonstrating Flexner-Wintersteiner rosettes (Fig. 4D) as well as in moderately and poorly differentiated regions (Fig. 4B). Here, CRX is linked to neoplasm.