These subtypes represented approximately 40% of medulloblastoma cases, similar to our findings, and had increased RNA expression of the photoreceptor transcription factors CRX, NRL and NR2E3. In addition, they were associated with clinical presentation at a younger age (<3 years of age) and more aggressive biological behavior with an increased risk of metastases at the time of diagnosis. Here, CRX is linked to medulloblastoma.