The anti-β1-AR autoantibodies are included in IgG3, and Staudt et al. [30] reported a significantly improved cardiac index and LVEF for patients with DCM treated by IA with an anti-IgG column that removed significantly more IgG3 (89±3%) than in patients with DCM treated by IA with a protein A column that removed only 37±4% of IgG3. The gene discussed is ADRB1; the disease is familial dilated cardiomyopathy.