The heart is a mast cell-rich organ and serum IgE levels were found to be significantly higher in the patients with unstable angina and acute myocardial compared to stable angina pectoris and controls, indicating that IgE might play a role in the pathogenesis of unstable angina pectoris and acute myocardial infarction [88]. Here, IGHE is linked to acute myocardial infarction.