RASSF1 and Familial prostate cancer: Furthermore, several findings indicate that RASSF1A methylation occurs at different stages of prostate cancer development as reported in PIN lesions (Kang et al. 2004; Aitchison et al. 2007) and advanced tumors (Kang et al. 2004; Maruyama et al. 2002; Liu et al. 2002).