In prostate cancer, RASSF1A methylation is either frequently detected in tissue samples or not (Kang et al. 2004; Yegnasubramanian et al. 2004; Woodson et al. 2004a; Woodson et al. 2004b; Maruyama et al. 2002; Liu et al. 2002; Kuzmin et al. 2002) and in the latter case it has been a correlated with prostate-specific antigen level or disease stage (Kang et al. 2004; Yegnasubramanian et al. 2004; Woodson et al. 2004a). The gene discussed is RASSF1; the disease is Familial prostate cancer.