APC and Familial adenomatous polyposis: The adenomatous polyposis coli (APC) gene encodes a multifunctional protein that plays a role in Wnt signaling pathway, cell migration, cell adhesion, and mitosis; it is also known to act as a tumor suppressor gene in familial adenomatous polyposis (Fearnhead et al. 2001; Nathke, 1999).