VEGFA and neoplasm: Solid tumors cannot grow beyond 2 to 3 mm in diameter without recruitment of their own blood supply, thus tumor angiogenesis results from a balance between endogenous activators [vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) etc.] and inhibitors [various antiangiogenic peptides generated from VBM or extracellular matrix (ECM) degradation by proteases] (Folkman, 1995a; Kieran et al. 2003; Folkman, 2003).