Mutation of the ECM protein laminin-1 leads to severe lens defects in zebrafish (Gross, et al. 2005; Zinkevich et al. 2006; Lee and Gross, 2007) with adults displaying strikingly similar phenotypes to our β1-integrin and ILK mutants including aphakia, lens cellular disorganization and reduced eye size. This evidence concerns the gene ILK and congenital primary aphakia.