Therefore, one potential explanation for the divergence of findings between the Ugandan and South African studies may be attenuated efficacy of MC for HIV prevention in older men with more chronic herpes infections, due to recruitment of CD4+ T cells and immature dendritic cells into areas of HSV-2 replication even months after resolution of lesions [22],[23]. The gene discussed is CD4; the disease is Herpesviridae infectious disease.