Intravenous, subcutaneous or intra-pleural administration of IL-2 has shown some effects on tumour regression in MPM, supporting the use of IL-2 in clinical trial settings (Goey et al, 1995; Astoul et al, 1998; Castagneto et al, 2001; Mulatero et al, 2001; Lucchi et al, 2007). This evidence concerns the gene IL2 and neoplasm.