CYP2C9 and breast carcinoma: Since the LD between CYP2C8*3 and CYP2C9*2 was incomplete, we also examined the effect of each SNP separately in the model, and while CYP2C8*3 was associated with significant increased hazard of early breast cancer-related events, CYP2C9*2 was associated with non-significant decreased hazard.