To determine whether CpG island methylation directly mediates CCBE1 silencing, we compared CCBE1-expression levels in ovarian cancer cell lines before and after treatment with the methyltransferase inhibitor 5-aza-2′-deoxycytidine (5-AZA) with or without the histone deacetylase inhibitor TSA. Here, CCBE1 is linked to ovarian carcinoma.