However, over-expression of BAH/AAH has been reported in a number of carcinomas (Lavaissiere et al, 1996; Cantarini et al, 2006) in which it mediates increased cellular motility/migration and invasion through hydroxylation of proteins containing the Asp/Asn consensus site (Engel, 1989; Gronke et al, 1989; Lieber et al, 1992; Monkovic et al, 1992; Sepe et al, 2002; Maeda et al, 2003; de la Monte et al, 2006), which is linked to cellular transformation (Ince et al, 2000). This evidence concerns the gene ASPH and carcinoma.