CCBE1 and neoplasm: CCBE1 maps to 18q21.32, a common region of loss of heterozygosity (LOH) in ovarian cancer (Takakura et al, 1999; Lambros et al, 2005) that is associated with malignant progression of ovarian cancer (Hauptmann et al, 2002) and high tumour grade and poor survival (Lassus et al, 2001).