In addition, this unfavourable effect of TOPK expression on outcome was maintained in multivariate analysis, suggesting that TOPK could represent an important prognostic factor in patients with KRAS-mutated or BRAF-mutated tumours (Andreyev et al, 1998; Samowitz et al, 2005; French et al, 2008; Ogino et al, 2009). This evidence concerns the gene KRAS and neoplasm.