TP53 and malignant colon neoplasm: To understand the functional relevance of the association between PRL-3 and integrin signaling, we firstly transfected PRL-3 cDNA or vector control into human colon cancer cell line LoVo, which has no detectable PRL-3 protein expression even in the presence of genotoxic stress by Adriamycin [see Additional file 1], which stabilized p53, a known PRL-3 inducer at transcriptional level [23].