There seems to be no or only weak correlation between YKL-40 and hsCRP in studies of patients with diabetes, obesity or atrial fibrillation [31-34] whereas a positive correlation is found between YKL-40 and hsCRP in studies of patients with manifest coronary artery disease (CAD) [35,36]. This evidence concerns the gene CHI3L1 and obesity due to melanocortin 4 receptor deficiency.