Deletion of LPA1 reduced fibroblast recruitment and vascular leak in the bleomycin model of pulmonary fibrosis [29] while LPA/LPA2 signaling via αvβ6 integrin-mediated activation of TGF-β has been implicated in the development of bleomycin-induced lung fibrosis in mice [54]. This evidence concerns the gene LPAR1 and pulmonary fibrosis.