Snail is a zinc-finger transcription factor that is expressed in migratory processes during embryonic development(38) and has been implicated recently in the phenotypic changes in colon cancer cells from an epithelial to a mesodermal morphology as the cells take on metastatic potential.(39,40) In the colon cancer cells, upregulated Snail is inversely correlated with cellular dedifferentiation and low VDR expression. The gene discussed is VDR; the disease is malignant colon neoplasm.