SNAI1 and malignant colon neoplasm: Snail is a zinc-finger transcription factor that is expressed in migratory processes during embryonic development(38) and has been implicated recently in the phenotypic changes in colon cancer cells from an epithelial to a mesodermal morphology as the cells take on metastatic potential.(39,40) In the colon cancer cells, upregulated Snail is inversely correlated with cellular dedifferentiation and low VDR expression.