NO levels played a role also in the uptake of tumour cells by DCs and in the further DCs-elicited lymphocytes activation: indeed the presence of SNP was sufficient to increase the phagocytosis of HT29 iNOS- cells by DCs (Fig 9A and 9B) and the subsequent expansion of lymphocytes in response to DCs (Fig 9C), whereas the addition of PTIO reversed these effects. This evidence concerns the gene NOS2 and neoplasm.