Therefore, the serological investigation of S. gallolyticus in this study has shown 4 factors of reliability; the statistical significance of S. gallolyticus association with both adenomas and CRC, no similar association was seen by the indicator bacteria B. fragilis, relying on the measurement of IgG rather than IgM antibodies which reflects better the status of longstanding immune reaction against bacterial antigens, and the agreement of our results with other studies that based on isolating S. gallolyticus from blood at the bacteremic phase. This evidence concerns the gene CD40LG and adenoma.